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pentobarbital will reduce the level or impact of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.pentobarbital decreases levels of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. CYP3A4 inducers maximize rate of toremifene metabolism, lowering the steady-state concentratio